Vascular mineralocorticoid receptor activation and disease
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor activation promotes vascular cell calcification.
OBJECTIVE Clinical studies demonstrate that mineralocorticoid receptor (MR) antagonism improves outcomes in cardiovascular patients and that vascular calcification correlates with adverse cardiac events. We have recently demonstrated that human vascular smooth muscle cells (VSMCs) express functional MRs that, in response to aldosterone, modulate expression of osteogenic genes including alkaline...
متن کاملVascular mineralocorticoid receptor and blood pressure regulation.
The mineralocorticoid receptor (MR) is a major regulator of blood pressure by modulating sodium balance and blood volume in the distal nephron. The discovery of MR expression in both endothelial and vascular smooth muscle cells a decade ago raised questions about its role in the vascular wall and its involvement in blood pressure regulation. In vitro and in vivo pharmacological studies have sho...
متن کاملMineralocorticoid receptor activation and oxidative stress.
The spontaneously hypertensive rat (SHR) has been extensively used in studies of hypertension for decades. More recently, a leptin receptor– deficient SHR (SHR/ NDmer-cp; SHR/cp) has been developed as a model for the human metabolic syndrome, characterized by elevated blood pressure, visceral obesity, glucose intolerance, and dyslipidemia. In this issue of Hypertension Nagase et al1 have used t...
متن کاملMineralocorticoid Receptor–Mediated Vascular Insulin Resistance
Two-thirds of adults in the U.S. are overweight or obese, and another 26 million have type 2 diabetes (T2D). Patients with diabetes and/or the metabolic syndrome have a significantly increased risk of heart attack and stroke compared with people with normal insulin sensitivity. Decreased insulin sensitivity in cardiovascular tissues as well as in traditional targets of insulin metabolic signali...
متن کاملMineralocorticoid receptor activation and mineralocorticoid receptor antagonist treatment in cardiac and renal diseases.
C ardiac and renal diseases remain major challenges for healthcare systems in developed countries and commonly coexist, with a disorder in the heart or kidney often leading to secondary dysfunction or injury in the other organ. Indeed, the term cardiorenal syndrome has been introduced to describe the broad spectrum of disease involving both the heart and kidneys. 1 Aldosterone is a steroid horm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2019
ISSN: 0014-4835
DOI: 10.1016/j.exer.2019.107796